Types of Services Provided: Cytogenetics
KaryoLogic, Inc. is a small woman-owned company based out of Research Triangle Park, NC that specializes in chromosome analysis of human and mouse cell lines used in biomedical research. KaryoLogic accepts specimens of live cell cultures shipped from around the globe. Most of the work focuses on traditional G-banded karyotyping to characterize novel cell lines, verify chromosome constitutions, detect culture cross contamination, and track chromosome changes over time in culture. Chromosome images and accompanying reports produced by highly experienced technologists provide detailed information to aid investigators in their research. Since 2009 KaryoLogic has been offering services to over 50 clients from university and government research laboratories, as well as private therapeutics industry.
Presently KaryoLogic is expanding into other areas of chromosome analysis, in particular, methylation assays. Fluorescent anti 5-methylcytosine antibodies bound to metaphase chromosomes can be used to provide information on epigenetic changes in human or mouse cell lines or primary cultures.
Karyologic is a Silver sponsor and donating 10 chromosome methylation assays to the Rare Disease Challenge. The results may elucidate chromosomal regions of altered methylation in rare diseases that warrant further investigation, or may be used to compare methylation patterns between parents and offspring in rare diseases. Submitted specimens should contain live mitotically active cells. Further instructions for preparing and shipping cells can be found on the company website. Investigators will receive a minimum of 2 fluorescent karyotype images per assay with a summary report identifying chromosomal regions of relative high and low binding of the fluorescent antibodies.
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